Coronavirus disease 2019 (COVID-19): a brief overview of features and current treatment

Since the report of first cases pneumonia caused by SARS-CoV-2 in December 2019, COVID-19 has become a pandemic and is globally overwhelming healthcare systems. The symptoms vary from asymptomatic infection to severe complicated with acute respiratory distress syndrome (ARDS) multiple organ failure leading death. estimated case-fatality rate among infected patients Wuhan, city where case appeared, was 1.4%, 5.1 times increase death those aged above 59 years than 30–59 years. In absence proven effective licensed treatment, many agents that showed activity against previous coronavirus outbreaks such as SARS MERS have been used treat infection. reported be 80% homologous SARS-CoV, some enzymes are almost 90% homologous. Antiviral drugs urgently required reduce fatality-rate hospitalizations relieve burden on systems worldwide. Randomized controlled trials ongoing assess efficacy safety several treatment regimens.